How BioMS Technologies can be Used in Your Research Projects

The aim of BioMS is to facilitate MS-based research of national importance, to address biological mass spectrometric applications in life science. On this page you can get an overview of the usage areas for our focus technologies.

Photo: Tobias Ohlsson/KI

Glycomics and Glycoproteomics

Glycomics: Glycans (N-,O-, free), glycolipids, GAGs
Glycoproteomics: Glycan sites on proteins

Biological samples consist of many glycoconju gates that can be analyzed by advanced MS to give a complete molecular detail of the type of glycoconjugates present. These technologies can be used for example to:

• Examine if your purified protein is a glyco-protein, and if so what glycans does it contain

• Find out if there are any qualitative or quantitative differences in the glycoproteome of your cell line or tissue samples

Protein Structure

Protein interactions

HDX is a very powerful technique for protein structure analysis. This technology can be used for example to:

• Examine the dynamics of protein conformation

• Determine sites of protein-ligand interactions

Targeted Proteomics

Screening of proteins in tissue or cells using MS

Targeted proteomics is a way to simultaneously determine the protein abundance for a selected set of proteins. This technology can be used for example to:

• Perform accurate and sensitive quantification of a selected set of proteins

• Quantify proteins lacking specific antibodies

Proteogenomics

Novel genes and gene products found by proteomics

In proteogenomics, sample specific genomics and transcriptomics information is combined with MS-based proteomics data. This technology can be used for example to:

• Analyze impact of genome changes in the proteome

• Improve genome annotation

• Do a systems biology study on DNA, RNA and protein levels

Chemical Proteomics

Using chemistry for functional proteomics

Chemical proteomics are powerful MS-based approaches for identifying proteome-wide compound-target interactions. This technology can be used for example to:

• Discover target protein for your molecule

• Analyze off-target landscape

• Improve your drug discovery pipeline

• Find out when and how a drug binds a target protein

Lipidomics

Lipids present in tissues and cells

Lipidomics covers the system-level analysis and characterization of lipids and related compounds. This technology can be used for example to:

• Understand how a disease or treatment
effects lipids in a sample

• Measure the different lipid classes and
fatty acids present in a sample

• Determine changes to lipid signalling
molecules

Quantitative Clinical Peptidomics

Screening of natural peptides

Quantitative targeted proteomics is a highly sensitive and selective method which can be used for quantitation of selected proteins/peptides in complex biological samples such as cerebrospinal fluid.

Large Scale Quantitative Proteomics

Critical insights in global protein expression

Global quantitative proteomics is a powerful strategy to analyse and understand protein changes in biopsies, cells, body fluid or other biological material.

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